Original title: Generating Medical Image Counterfactuals using Causal Explanations
David A. Kelly, Tom Yaacov, Nathan Blake, Sander Beckers +1 · September 2026
Doctors hesitate to use deep learning for medical diagnosis because they cannot see how the computer makes decisions. One way to test a model is with counterfactual imagesModified images that show what would cause the AI to change its diagnosis.. These show how a scan must change to flip the model's diagnosis. Usually, researchers make these using complex second tools like generative adversarial networksAI models that create new images by having two networks compete. or diffusion modelsAI models that generate images by gradually refining noise.. But using a second black-box model muddies what the first model is actually seeing. To solve this, researchers built a method that needs no generative model or extra training. Instead, it extracts causal evidenceDirect information from the AI that influences its predictions. straight from the classifier to make deterministic edits in specific regions of interest. On real-world medical datasets, this altered predictions while staying closer to the original images than generative tools.
You're judging whether a painting is authentic by looking at it. If you want to test your judgment, you might ask an art expert to suggest a change, but that expert has their own style. In this paper, the method examines the painting's actual features to show exactly what alteration would make you call it a fake, without relying on another opinion.
Clinicians need to trust AI diagnoses, but current tools are hard to explain. This method makes the AI's reasoning more transparent, helping doctors and patients feel confident in the technology.
The abstract does not specify which medical imaging datasets were used, how many experiments were conducted, or provide detailed performance metrics. It also does not address how the method handles highly complex or ambiguous cases in medical diagnosis.
Ask anything about this paper. Answers come from its abstract, and say so when the abstract doesn't cover your question.
Generating Medical Image Counterfactuals using Causal Explanations — David A. Kelly, Tom Yaacov, Nathan Blake et al.
Abstract licence: CC0
Explanation generated by Synthesis from the abstract — it is not the original paper. This is a preprint, so it hasn't necessarily been peer reviewed.