Original title: Early Gastric Cancer Detected During 15-year Surveillance After Ménétrier Disease Remission and Successfully Treated With Endoscopic Submucosal Dissection: A Case Report
Takaaki Shamoto, Hideko Yamamoto, Takehito Naito, Masahiro Yamada +5 · August 2026
Ménétrier disease is a rare stomach condition where the stomach lining develops giant folds and leaks proteins, raising cancer risks. Doctors treated a woman in her 70s who had this illness. Steroid medicine put the disease into remission, and a daily stomach acid blocker kept it from returning. Because this disease can trigger stomach cancer, doctors checked inside her stomach every year with a tiny camera called an endoscope. Fifteen years later, they spotted an early-stage cancer on her stomach wall. The original disease had not returned. Doctors used a special procedure to carve out the cancer in one whole piece without major surgery. The cancer was completely removed, and neither the tumor nor the original disease came back. This shows why patients need yearly stomach checks even years after recovering.
Imagine you have a garden that once had a persistent weed problem. You sprayed it and the weeds disappeared. But you still check the garden every spring. Fifteen years later, you spot a single weed sprout and pull it out before it spreads. In this paper, the weed problem corresponds to Ménétrier disease, the spraying to steroid therapy, the yearly checks to endoscopic surveillance, and the single weed to an early gastric cancer detected and removed endoscopically.
Patients with Ménétrier disease, even after successful treatment, remain at risk for gastric cancer years later. This case shows that regular endoscopic screening can catch cancer early enough for minimally invasive removal. It underscores that remission does not eliminate the need for continued monitoring.
This is a single case report, so findings may not apply to all Ménétrier disease patients. The abstract does not specify the optimal surveillance interval or duration. It does not compare outcomes with other surveillance strategies or treatments. The patient was in her 70s, so age-related factors may be relevant.
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Early Gastric Cancer Detected During 15-year Surveillance After Ménétrier Disease Remission and Successfully Treated With Endoscopic Submucosal Dissection: A Case Report — Takaaki Shamoto, Hideko Yamamoto, Takehito Naito et al. — DEN open — doi:10.1002/deo2.70389
Abstract licence: CC BY
Explanation generated by Synthesis from the abstract — it is not the original paper.