Removing many duodenal polyps at once prevented surgery for five years in a genetic condition.

People with an inherited condition called familial adenomatous polyposis often develop many small, precancerous growths in their small intestine. Removing these growths usually takes multiple visits over time, which can still leave patients at risk of major surgery or cancer. Doctors tested an aggressive approach called intensive downstaging polypectomies, where they remove at least three growths during a single procedure. By clearing out larger numbers of growths in one go, doctors aim to lower the overall tumor burden and reduce cancer risk. Researchers followed patients over a long period to see if this method worked. It proved safe and effective. Removing multiple growths cut the disease severity stage in half of the patients who received it. None of these patients suffered punctures or delayed bleeding, and none needed major surgery to remove the duodenum during the follow-up period.

Why it matters

For people with familial adenomatous polyposis, duodenal polyps often lead to surgery to prevent cancer. This study shows that removing many polyps at once during endoscopy can safely reduce the polyp burden and avoid the need for surgery for at least five years, even in advanced cases. That means a less invasive option with fewer complications and preserved digestive function.

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