Original title: Distinct functional roles of Lactobacillus strains in modulating lipid metabolism, adipose accumulation, inflammatory responses, and carcass characteristics in heavy finishing pigs
Boyang Wan, Qiuyu Zeng, Linjuan He, Xu Qin +6 · July 2026
Farmers want better ways to manage animal fat and meat quality, but scientists do not fully understand how different beneficial gut bacteria, called probiotics, compare. Researchers tested this by feeding heavy finishing pigs two different bacterial strains: Lactobacillus reuteri and Lactobacillus johnsonii. Both bacteria lowered stress hormones and inflammation while raising antioxidant defenses. However, each strain worked differently inside the body. Lactobacillus johnsonii turned on a biological switch called the AMPK/PPARγ signaling pathway. This pathway speeds up the breakdown of fat and slows fat production. As a result, pigs eating this strain had smaller fat cells and thinner backfat. In contrast, Lactobacillus reuteri did not focus on overall fat reduction. Instead, it improved meat quality traits. It made the pork more tender, lowered intramuscular fat, and raised levels of specific amino acids, which are the building blocks of protein. The results show that different strains do distinct jobs.
Imagine you are a chef trying to improve a dish. You have two different spices. One spice makes the dish less oily, the other makes the meat more tender. But you cannot use both at once because they work in opposite ways. In this paper, two types of bacteria fed to pigs had similarly distinct effects: one reduced backfat, the other improved meat quality.
Pork producers can now choose specific probiotics to either reduce backfat or improve meat tenderness. This means more efficient production of lean pork or higher-quality pork for consumers. The study shows that not all probiotics work the same way, so targeted use can save costs and improve outcomes.
The abstract doesn't state limitations explicitly, but the study is limited to two strains, a single dose, heavy finishing pigs, and a 42-day period. It does not establish effects in other pig breeds, lighter pigs, or longer durations. The molecular mechanism is only suggested for L. johnsonii via AMPK/PPARγ, but not confirmed with further experiments.
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Distinct functional roles of Lactobacillus strains in modulating lipid metabolism, adipose accumulation, inflammatory responses, and carcass characteristics in heavy finishing pigs — Boyang Wan, Qiuyu Zeng, Linjuan He et al. — Animal nutrition (Zhongguo xu mu shou yi xue hui) — doi:10.1016/j.aninu.2026.03.006
Abstract licence: CC BY
Explanation generated by Synthesis from the abstract — it is not the original paper.