Original title: Disseminated Klebsiella pneumoniae Infection Mimicking Multiple Colonic Subepithelial Lesions: A Case Report
Yoshiaki Kobayashi, Tadanobu Nagaya, Mai Iwaya, Hiroshi Ikeuchi +3 · September 2026
Unusual growths in the colon often look like cancer. Doctors examined a 73-year-old man who had diarrhea, swelling called edema, and low red blood cells known as anemia. A camera test showed bumps that resembled tumors called subepithelial lesionsGrowths or bumps that appear under the lining of the colon, often raising concern for cancer. all along his colon. Ultrasound imaging revealed swelling in the inner gut layers. When doctors tested tissue samples, they found inflammation caused by the bacterium Klebsiella pneumoniae. Further checks showed the infection had spread widely, affecting his heart lining, his spine, and his pacemaker wires. Instead of needing cancer treatment, the patient received targeted germ-fighting antibiotics and medical care for his device. His colon bumps cleared up. This shows that widespread bacterial infections can mimic bowel tumors.
You spot small bumps on your living room wall. Your first thought is termite damage or a structural problem. After testing, you learn it is just a water stain from a minor leak that dries up once you fix the plumbing. In this paper, the colonic bumps looked like cancer but were actually caused by a bacterial infection that cleared up after antibiotics, avoiding unnecessary surgery.
For patients with multiple colon growths, this case reminds doctors that sometimes the cause is an infection, not cancer. This distinction is critical because treatment changes completely: antibiotics instead of chemotherapy or surgery. Anyone with systemic signs like fever or heart infection should be checked for infection as a potential culprit.
This is a single case report, so the pattern may not apply to all patients with similar colon findings. The patient had multiple other infection sites, which may have contributed to the unusual presentation. Long-term outcomes are not reported. Causal inference is limited by the observational nature of the report.
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Disseminated Klebsiella pneumoniae Infection Mimicking Multiple Colonic Subepithelial Lesions: A Case Report — Yoshiaki Kobayashi, Tadanobu Nagaya, Mai Iwaya et al. — DEN open — doi:10.1002/deo2.70431
Abstract licence: CC BY
Explanation generated by Synthesis from the abstract — it is not the original paper.