Original title: Transition from inflammation to proliferation: a critical step during wound healing
Healing has stages: first, inflammation helps the body respond to injury; later, cells begin rebuilding damaged tissue. This review focuses on the switch between those stages. It describes cell and molecule processes that may control the switch, and how a faulty transition is linked to wound-healing problems. The authors argue that finding these controls could help guide new treatments.
After a plate breaks, you clear away the sharp pieces before setting out a new meal. If clearing the mess takes too long, you cannot get to the rebuilding and serving. In this paper, clearing the damage stands for inflammation, setting out the meal stands for rebuilding tissue, and the difficult shift between them is the focus.
People with hard-to-heal ulcers need treatments that help restore the skin barrier, but effective ways to speed healing and reduce scarring are still lacking. Understanding the shift from inflammation to tissue growth may point researchers toward new treatment targets.
The abstract describes a review and says that identifying mechanisms may reveal treatment targets. It does not report specific mechanisms, tested treatments, or evidence that any proposed target improves healing or reduces scarring.
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Transition from inflammation to proliferation: a critical step during wound healing — Ning Xu, Dongqing Li, Mona Ståhle — Cellular and Molecular Life Sciences — doi:10.1007/s00018-016-2268-0
Abstract licence: CC BY
Explanation generated by Synthesis from the abstract — it is not the original paper.