Original title: Skin tissue engineering: wound healing based on stem-cell-based therapeutic strategies
Wound healing normally unfolds in several stages, with cells and chemical signals coordinating the repair. When a stage goes wrong, a wound can become chronic or leave an abnormal scar. This review examines research on embryonic, induced pluripotent, and adult stem cellsCells found in the body that can make certain other cell types and help maintain or repair tissue. as possible treatments. It describes how these cells may help wounds heal and regenerate skin, as well as the challenges of using them.
Imagine repairing a tear in a favorite shirt while several people pass fabric, thread, and instructions along the way. If one step fails, the tear may stay open or the repair may leave a rough patch. In this paper, the repair is wound healing, the helpers are the cells and signals involved, and stem-cell treatments are possible ways to help restore the damaged skin.
Chronic wounds can mean repeated treatment, high medical costs, and a lower quality of life. This review looks at stem-cell strategies that may improve wound healing and skin regeneration, while also describing obstacles that still need to be addressed.
The abstract describes a review of published data, but gives no specific study results, comparisons between stem-cell types, or details about which challenges are most important. It does not establish that stem-cell treatments are safe or effective for patients.
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Skin tissue engineering: wound healing based on stem-cell-based therapeutic strategies — Azar Nourian Dehkordi, Fatemeh Mirahmadi, Mohammad Chehelgerdi et al. — Stem Cell Research & Therapy — doi:10.1186/s13287-019-1212-2
Abstract licence: CC BY
Explanation generated by Synthesis from the abstract — it is not the original paper.