Original title: Muscle–Organ Crosstalk: The Emerging Roles of Myokines
Muscles do more than move the body: when they work during exercise, they release chemical signals called myokinesChemical signals released by muscle cells that can affect the same tissue or other parts of the body.. These signals can act on the muscle itself or travel to other organs, including the brain, liver, and bones. Different myokines may affect processes such as blood sugar use, memory, and bone formation. Researchers are exploring whether these signals could help monitor exercise, but only a few have a clear, specific role established in humans.
After cooking, you might send food to different rooms while keeping some for the kitchen. The hard part is that one dish can affect several people, and you may not know who got what or what it changed. In this paper, the food is the signal released by working muscles, and the rooms are other organs; the signals can affect nearby tissue or travel farther through the body.
Exercise affects more than the muscles doing the work. Understanding the chemical signals muscles release could help researchers track how exercise affects people with conditions such as diabetes, cancer, or neurodegenerative disease, though the abstract says only a few signals have a specific function established in humans.
The abstract says only a few myokines have been assigned a specific function in humans. It suggests that myokines may be useful biomarkers for monitoring exercise prescription, but does not establish that they work as clinical monitoring tools or describe evidence for particular patients or treatments.
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Muscle–Organ Crosstalk: The Emerging Roles of Myokines — Mai Charlotte Krogh Severinsen, Bente Klarlund Pedersen — Endocrine Reviews — doi:10.1210/endrev/bnaa016
Abstract licence: CC BY
Explanation generated by Synthesis from the abstract — it is not the original paper.