Original title: Anti-Inflammatory and Immunomodulatory Effects of Probiotics in Gut Inflammation: A Door to the Body
The gut is home to many microbes, and the immune system must protect the body without attacking helpful ones. This review describes evidence that probiotics may support the gut lining, which helps keep microbes and their products from leaking into the body. They may also affect immune cells and reduce signals linked to inflammation. The exact mechanisms are still unclear, and factors such as diet and medication may affect the results.
Imagine a kitchen door that keeps the cooking area separate from the rest of the house. If its seal weakens, smells and mess can spread, and everyone may rush in to deal with them. In this paper, the door seal stands for the gut lining, while probiotics are discussed as a possible way to support that barrier and avoid needless immune responses.
People with gut inflammation may be affected by changes in the microbes living in their intestines. This review describes ways probiotics might support the gut barrier and limit unnecessary immune activation, but it also notes that diet, age, medications, stress, and other factors can change their effects.
The review says the precise mechanisms of probiotic effects are not well defined. It also notes that diet, age, BMI, medications, stress, gut function, and other factors may affect the microbiome and confound benefits. The abstract does not establish how effective probiotics are for a particular condition or which probiotic should be used.
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Anti-Inflammatory and Immunomodulatory Effects of Probiotics in Gut Inflammation: A Door to the Body — Fernanda Cristofori, Vanessa Nadia Dargenio, Costantino Dargenio et al. — Frontiers in Immunology — doi:10.3389/fimmu.2021.578386
Abstract licence: CC BY
Explanation generated by Synthesis from the abstract — it is not the original paper.