Original title: Osteoporosis Due to Hormone Imbalance: An Overview of the Effects of Estrogen Deficiency and Glucocorticoid Overuse on Bone Turnover
Bones are continually broken down and rebuilt. Estrogen helps slow bone breakdown and supports the cells that build bone, so too little estrogen can make breakdown outpace rebuilding. Too much glucocorticoidA type of steroid medicine that can affect bone when used excessively. medicine can also weaken bones by reducing bone-building cells and increasing bone breakdown. The review describes these processes, risk factors, and treatments, while noting that medication safety and effectiveness need more study.
Imagine a household where some people take apart worn furniture while others repair and rebuild it. Trouble starts when the taking-apart outpaces the repairs, or when too few people are available to rebuild. In this paper, taking furniture apart stands for bone breakdown, rebuilding stands for bone formation, and hormone changes or excess medicine can shift the balance between them.
This review matters to aging postmenopausal women and people who use glucocorticoid medicines, because both estrogen deficiency and excess glucocorticoids can raise osteoporosis risk. The causes differ, so prevention and treatment may differ too.
The review notes that more detailed understanding of both conditions is needed, along with further investigation of the safety and effectiveness of osteoporosis medicines. The abstract does not report original experiments or comparative treatment results.
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Osteoporosis Due to Hormone Imbalance: An Overview of the Effects of Estrogen Deficiency and Glucocorticoid Overuse on Bone Turnover — Chu-Han Cheng, Li-Ru Chen, Kuo-Hu Chen — International Journal of Molecular Sciences — doi:10.3390/ijms23031376
Abstract licence: CC BY
Explanation generated by Synthesis from the abstract — it is not the original paper.