Original title: Multimodal neuroimaging in dementia and neurodegenerative disorders: complementary roles of clinically available nuclear medicine and MRI in the era of disease-modifying therapies
Anti-amyloid treatments make brain scans important for deciding who may be eligible. A PETA scan that uses a small amount of radioactive tracer to show particular substances or activity in the body. scan can show amyloid, a protein linked to Alzheimer’s disease, but amyloid can also appear in older people with normal thinking and in other disorders. MRI and other scans can show brain damage or changes in brain function. Reading several scans together gives clinicians different clues, especially when the results do not match.
Imagine sorting a pile of laundry by checking one label. That label may tell you the fabric, but it cannot tell you whether the clothes are stained, worn, or still usable. In this paper, amyloid scans are like checking that label, while MRI and other brain scans offer different clues about damage and function; putting them together can give a fuller picture.
People being considered for anti-amyloid treatment need more than a yes-or-no answer about amyloid. Combining brain scans can help clinicians assess damage, function, and possible causes, supporting treatment decisions and a more accurate reading of symptoms.
The abstract describes a review of the roles of clinically available imaging, but gives no details about the evidence-selection method or comparative accuracy of particular scan combinations. It says multimodal imaging may improve diagnostic accuracy; it does not establish how much it improves outcomes or whether it changes treatment results.
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Multimodal neuroimaging in dementia and neurodegenerative disorders: complementary roles of clinically available nuclear medicine and MRI in the era of disease-modifying therapies — Yoshitaka Inui, Hajime Takechi, Hirohisa Watanabe et al. — Japanese Journal of Radiology — doi:10.1007/s11604-026-02080-9
Abstract licence: CC BY
Explanation generated by Synthesis from the abstract — it is not the original paper.